Anti-aging potentials of a polyphenol-rich supplement from African Sorghum bicolor leaf sheaths: A narrative review

Abstract :

Aging is a complex biological process marked by a gradual decline in physiological functions and systemic deterioration, resulting in increased susceptibility to age-related diseases. There is increasing interest in the use of plant-based constituents in mitigating oxidative stress and inflammation, the major drivers of aging and age-related diseases. Polyphenol-rich plant-based constituents including Sorghum bicolor supplement (SBS) with potent antioxidant, anti-inflammatory and neuroprotective properties, have demonstrated anti-aging potential. The aim of this review is to provide documentation from published literature on the anti-aging potentials of SBS that may elicit the need for its clinical evaluation for age-related diseases. A literature search was conducted using PubMed electronic database with subject headings, related to the mechanisms of aging, age-related diseases, health burden of aging population, and polyphenols for a healthy life span. It also included the source, bioactive constituents, and antiaging potential of SBS. The findings obtained from the review showed that SBS mitigated age-related diseases in various animal models. The supplement extended the life span of Drosophila melanogaster and improved their motor functions. The SBS inhibited the activity of collagenase and elastase enzymes involved in premature skin aging and exhibited cytoprotection against hyposaline-induced red blood cells hemolysis. The anti-aging potential of SBS relates to its potent antioxidant, anti-inflammatory, immune-modulating, and neuro-protective properties. These findings provide a strong foundation for further preclinical and clinical studies to validate the therapeutic potentials of SBS in promoting a healthier lifespan and enhancing the quality of life of the aging population.

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Citation :

Adeleke et al. Anti-aging potentials of a polyphenol-rich supplement from African Sorghum bicolor leaf sheaths: A narrative review. Mediterr J Pharm Pharm Sci. 2025; 5(4): 58-77. [Article number: 231]. https://doi.org/10.5281/zenodo.17742769