Chemical analysis and analgesic activity of methanol extract of Crinium Jagus bulb in BALB/c mice

Abstract :

Crinum jagus, family- Amaryllidaceae, commonly called river lily is an important medicinal plant used in the treatment of cough. It is an anti-venom agent used among the rural people in south-western Nigeria. The research aims to investigate the phytochemical constituents and analgesic activity of Cinium jagus bulb in BALB/c mice. The bulb was extracted with methanol in a soxhlet extractor apparatus. Phytochemical screening was performed according to standard methods. The alkaloid fraction was obtained using separation by extraction and characterized by infra-red (I.R) analysis. An acute toxicity test was done before the analgesic activity was determined in BALB/c albino mice using the hot plate model. The result indicated the presence of some bioactive constituents like alkaloids, terpenoids and saponin. I.R bands were observed at 1064.74 cm 1 (C-O) stretch of alcohol; 1415.80 cm-1 (C-H) bend of alkyl groups and 1639.55 cm-1 (N-H) stretch of amine among others. The extract significantly increased the mean latency time of mice on the hot plate when compared with the control with 100 mg/kg at 120 minutes. This study indicates that the Crinum Jagus bulb possesses analgesic potential.

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Citation :

Iyekowa I, Oderanti AO (2023) Chemical analysis and analgesic activity of methanol extract of Crinium Jagus bulb in BALB/c mice. Mediterr J Pharm Pharm Sci. 3 (1): 19-25. [Article number: 100]. https://doi.org/10.5281/zenodo.7771339