Clinical profile of patients with diabetic foot ulcers at a Tertiary Care Hospital in Lahore Pakistan

Abstract :

Diabetic foot ulcers are moderately severe complications in patients with type 2 Diabetes Mellitus, with peripheral neuropathy and angiopathy often serving as risk factors. This study aimed to examine the clinical characteristics and risk factors linked to diabetic foot ulcers in type 2 diabetes mellitus individuals within the Pakistani demographic. A retrospective cross-sectional design was used, to analyze the medical files of 68 diabetic foot ulcer patients. Data were collected from the Departments of Medicine and Surgery at Chaudhary Muhammad Akram Teaching and Research Hospital, Lahore Pakistan from Sept. to Dec. 2024. Patients’ clinical profiles, including demographic data, diabetes duration, diabetes control, HbA1c levels, and the presence of comorbidities were all evaluated. Out of the 68 patients, 70.6% were male having a mean age of 55.6±11.7 years, and 55.9% had diabetes for seven years or more. With regard to clinical factors, 61.8% had peripheral neuropathy, 58.8% had hypertension, 47.1% had retinopathy, 26.5% had nephropathy, 20.6% had ischemic stroke, 8.8% had ischemic heart disease, and 2.9% had hypothyroidism, with 97.1% showing poor glycemic control. This study identified a high rate of comorbidities in patients with diabetic foot ulcers, with inadequate diabetes control being a major contributing factor. Timely detection and management of diabetes and its complications are crucial to alleviating the impact of diabetic foot ulcers.

References

1. Seshadri H, Karthikeyan V, Rudrakumar M, Seshadri P, Vasudevan D, Ranganathan V, et al. (2024) Out-of-pocket expenditure among patients with diabetic foot ulcer in a tertiary care hospital of south India: A cross-sectional study. International Wound Journal. 21 (4): e14552. doi: 10.1111/iwj.14552
2. Pradeepa R, Mohan V (2021) Epidemiology of type 2 diabetes in India. Indian Journal of Ophthalmology. 69 (11): 2932-2938. doi: 10.4103/ijo.IJO_1627_21
3. Butt NI, Ghoauri MSA, Sabeh D, Waris U, Waris B, Jabbar R (2024) Prevalence of hypertension and its association with diabetic complications in patients with type 2 diabetes mellitus at a Tertiary Care Hospital. Journal of Medical Research and Reviews. 3 (2): 58-63. doi: 10.5455/JMRR.20241016103141
4. Rastogi A, Bhansali A (2016) Diabetic foot infection: An Indian scenario. Journal of Foot Ankle Surgery. 3 (2): 71‐79. doi: 10.5005/jp-journals-10040-1052
5. Raghav A, Khan ZA, Labala RK, Ahmad J, Noor S, Mishra BK (2018) Financial burden of diabetic foot ulcers to world: a progressive topic to discuss always. Therapeutic Advances in Endocrinology and Metabolism. 9 (1): 29-31. doi: 10.1177/2042018817744513
6. Bal B, Khanna G, Bhardwaj A, Singh K (2019) Evaluation of risk factors for lower extremity amputation in diabetic foot ulcer: a hospital based observational study in Northern India. International Journal of Research in Medical Sciences. 7 (4): 1190-1195. doi: 10.18203/2320-6012.ijrms20191323
7. Butt NI, Ghoauri MSA, Dur-e-Sabeh, Hasnain M, Waris B (2024) Hyperuricemia in Patients with Type 2 Diabetes Mellitus at a Tertiary Care Hospital in Bahawalpur Pakistan. Sri Lanka Journal of Medicine. 33 (3): 28-34. doi: 10.4038/sljm.v33i3.549
8. Hosseini R, Rasoli A, Baradaran HR (2008) Diabetic foot ulcer risk factors in patients referred to diabetes clinic in Kamkar center in Qom in 2006. Qom University of Medical Sciences Journal. 2 (3): 25-32. doi: 20.1001.1. 17357799.1387.2.3.3.1
9. Pscherer S, Dippel FW, Lauterbach S, Kostev K (2012) Amputation rate and risk factors in type 2 patients with diabetic foot syndrome under real-life conditions in Germany. Primary Care Diabetes. 6 (3): 241-246. doi: 10.1016/ j.pcd.2012.02.004
10. Leese GP, Cochrane L, Mackie AD (2011) Measuring the accuracy of different ways to identify the 'at-risk' foot in routine clinical practice. Diabetic Medicine. 28 (6): 747-754. doi: 10.1111/j.1464-5491.2011.03297.x
11. Shahbazian H, Yazdanpanah L, Latifi SM (2013) Risk assessment of patients with diabetes for foot ulcers according to risk classification consensus of International Working Group on Diabetic Foot (IWGDF). Pakistan Journal of Medical Sciences. 29 (3): 730-734. doi: 10.12669/pjms.293.3473
12. Li X, Wen S, Dong M, Yuan Y, Gong M, Wang C, Yuan X, Jin J, Zhou M, Zhou L (2023) The metabolic characteristics of patients at the risk for diabetic foot ulcer: A comparative study of diabetic patients with and without diabetic foot. Diabetes, Metabolism Syndrome and Obesity. 16: 3197-3211. doi: 10.2147/DMSO.S430426
13. Guo Q, Ying G, Jing O, Zhang Y, Liu Y, Deng M, Long S (2023) Influencing factors for the recurrence of diabetic foot ulcers: A meta-analysis. International Wound Journal. 20 (5): 1762-1775. doi: 10.1111/iwj.14017
14. Armstrong DG, Boulton AJM, Bus SA (2017) Diabetic Foot Ulcers and Their Recurrence. The New England Journal of Medicine. 376 (24): 2367-2375. doi: 10.1056/NEJMra1615439
15. Atair ASM, Mohamed MAI, Abdelfadel AN, Ahmed HA, Atiya SA (2023) Knowledge and practice of foot care among Libyan diabetic patients. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 3 (1): 35-42. doi: 10.5281/zenodo.7771360
16. Rhayem NA, Ramah MM, El Khituni (2025) Knowledge and practice of diabetic foot care among diabetic patients in Libya. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 5 (1): 123-132. doi: 10.5281/zenodo. 14933622

Citation :

Butt et al. (2025) Clinical profile of patients with diabetic foot ulcers at a Tertiary Care Hospital in Lahore Pakistan. Mediterr J Pharm Pharm Sci. 5 (2): 31-35. [Article number: 198]. https://doi.org/10.5281/zenodo.15119155