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Received date : 02-06-2024 Revised date : 23-06-2024 Accepted date : 29-06-2024 Published date : 30-06-2024

Mediterr J Pharm Pharm Sci 4 (2): 75-81, 2024

DOI: https://doi.org/10.5281/zenodo.12601827

Short Communication


Determination of the structural parameters of Repaglinide in tablet: an antidiabetic drug, using Spectroscopic methods

Djawhara Haddad, Nasser Belboukhari, Khaled Sekkoum and Meriem Bouanini



Abstract :

The spectroscopy area provides molecular-level information about an anti-diabetic drug through qualitative and quantitative analysis, Repaglinide is an antidiabetic medication in the meglitinide class that is used to treat type II diabetes mellitus. The objective of this work was to characterize Repaglinide by using UV spectroscopy (UV), nuclear magnetic resonance (NMR), and infrared spectrometry (FTIR). The UV results showed that the maximum absorption was at 208, 243, and 285 nm. The IR spectra obtained are consistent with those described in the literature. The NMR-1H spectra revealed information about the various hydrogen and carbon atoms in the molecule as well as their chemical surroundings. The provided methods were successfully employed to control a drug with great accuracy and precision.

References

1. Varshosaz J, Minayian M, Ahmadi M, Ghassami E (2017) Enhancement of solubility and antidiabetic effects of Repaglinide using spray drying technique in STZ-induced diabetic rats. Pharmaceutical Development and Technology. 22 (6): 754-763.doi: doi: 10.3109/10837450.2016.1143001.
2. Dhole SM, Amnerkar ND, Khedekar PB (2012) Comparison of UV spectrophotometry and high performance liquid chromatography methods for the determination of repaglinide in tablets. Pharmaceutical Methods. 3 (2): 68-72. doi: 10.4103/2229-4708.103875
3. Kharbade S, Asnani A, Pratyush K (2019) Development and validation of UV spectrophotometric method for simultaneous estimation of metformin HCl and Repaglinide in pharmaceutical formulation. Journal of Drug Delivery and Therapeutics. 9 (3): 344-347. doi: 10.22270/jddt.v9i3.2676
4. Öge TÖ (2018) FT-IR, laser-Raman, UV-Vis, and NMR spectroscopic studies of antidiabetic molecule nateglinide. Journal of Spectroscopy. 8573014. 2018 (3): 1-12. doi: 10.1155/2018/8573014
5. Sharma S, Sharma MC (2011) UV-Visible spectrophotometry of Repaglinide in bulk and in formulation by using methyl orange as reagents. Journal of the Iranian Chemical Research. 4 (2): 69-76. doi: Nil.
6. Nicolescu C, Arama C, Monciu CM (2010) Preparation and characterization of inclusion complexes between repaglinide and β-cyclodextrin, 2-hydroxypropyl-β-cyclodextrin and randomly methylated β-cyclodextrin. Farmacia. 58 (1): 78-88. Corpus ID: 42642831.
7. Rajput S, Chaudhary B (2006) Validated analytical methods of repaglinide in bulk and tablet formulations. Indian Journal of Pharmaceutical Sciences. 68 (1): 130-132. doi: 10.4103/0250-474X.22987
8. Kancherla P, Keesari S, Alegete P, Khagga M, Das P (2018) Identification, isolation, and synthesis of seven novel impurities of anti‐diabetic drug Repaglinide. Drug Testing and Analysis. 10 (1): 212-221. doi: 10.1002/ dta.2207
9. Aslan SS, Yılmaz B (2017) Derivative spectrophotometric and isocratic high-performance liquid chromatog-raphic methods for simultaneous determination of repaglinide and metformin hydrochloride in pharmaceutical preparations. American Journal of Analytical Chemistry. 8 (9): 541-552. doi: 10.4236/ajac.2017.89039
10. AlKhalidi BA, Shtaiwi M, AlKhatib HS, Mohammad M, Bustanji Y (2008) A comparative study of first-derivative spectrophotometry and column high-performance liquid chromatography applied to the determination of repaglinide in tablets and for dissolution testing. Journal of AOAC International. 91 (3): 530-535. PMID: 18567297.
11. Nagarajan P, Rajendiran C, Naidu A, Dubey P (2013) Studies on diastereofacial selectivity of a chiral tert-butanesulfinimines for the preparation of (S)-3-methyl-1-(2-piperidin-1-yl-phenyl) butylamine for the synthesis of Repaglinide. Asian Journal of Chemistry. 25 (16): 9345-9350. doi: 10.14233/ajchem.2013.15539
12. Zhu Z, Yang T, Zhao Y, Gao N, Leng D, Ding P (2014) A simple method to improve the dissolution of repaglinide and exploration of its mechanism. Asian Journal of Pharmaceutical Sciences. 9 (4): 218-225. doi: 10.1016/j.ajps.2014.06.004
13. Hajare PP, Rachh PR (2021) Formulation and development of novel gastroretentive microballoons of Repaglinide. Journal of Advanced Scientific Research. 12 (04 Suppl 1): 193-204. doi: 10.55218/JASR.s 1202112421
14. Aramă C, Nicolescu C, Nedelcu A, Monciu C-M (2011) Synthesis and characterization of the inclusion complex between repaglinide and sulfobutylether-β-cyclodextrin (Captisol®). Journal of Inclusion Phenomena and Macrocyclic Chemistry. 70 (3-4):421-428. doi: 10.1007/s10847-010-9911-4
15. Gumieniczek A, Berecka-Rycerz A, Mroczek T, Wojtanowski K (2019) Determination of chemical stability of two oral antidiabetics, metformin and repaglinide in the solid state and solutions using LC-UV, LC-MS, and FT-IR methods. Molecules. 24 (24): 4430. doi: 10.3390/molecules24244430
16. Chashmniam S, Tafazzoli M (2017) Conformation of repaglinide: A solvent dependent structure. Journal of Molecular Structure. 1143: 388-396. doi: 10.1016/j.molstruc.2017.04.097
17. Belboukhari M, Othmane F, Belboukhari N, Sekkoum K (2022) Chiral analysis of Amlodipine by HPLC Methods. Aditum Journal of Clinical and Biomedical Research. 4 (2): 1-4. doi: 03.2022/1.1073

Citation :

Haddad et al. (2024) Determination of the structural parameters of Repaglinide in tablet: An antidiabetic drug, using Spectroscopic methods. Mediterr J Pharm Pharm Sci. 4 (2): 75-81. [Article number: 162]. https://doi.org/10.5281/zenodo.12601827

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