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Received date : 21-08-2023 Revised date : 28-09-2023 Accepted date : 28-09-2023 Published date : 30-09-2023

Mediterr J Pharm Pharm Sci 3 (3): 60-61, 2023

DOI: https://doi.org/10.5281/zenodo.10.5281/zenodo.8393129


Dosing in the neonatal intensive care unit

Nabila S. Hashad

Abstract :

Over the years, pharmacy has developed from a simple floor stock system to a complex unit dose, I.V.additive, and clinical pharmacy program. This development would have never been possible without the support of the nursing, medical, and administrative staff. The support of obtained slowly by developing services that increase the pharmacist's credibility as a team member concerned with the pediatric and neonate patients. These services include a unit dose program, I.V. additive program, drug information services, and pharmacy medication program. One area in which pharmacist does not obtain a background from generalized training is the area of pediatric dosing. Pediatric pharmacists must learn in clinical practice the proper dosing of the pediatric patient and neonate patient. The dose must be checked periodically. In the premature or newborn infant, the pharmacist must consider the immature renal and hepatic function so that he/she does not overdose initially and then underdose as the infant grows and matures. Neonates are a special group of children, they are less than 30 days, and within this group preterm babies(that means less than 37 weeks). Determining the correct dose for drugs used to treat neonates is a critically vital factor.Prematurity affects kidney and liver function and the proper adjustment of drug doses is crucial [1].The absence of drug levelnecessitatesthe adjustment of drug dosesand the presence of qualified oriented dependable pharmacists.Drug doses arenotnumbers, or decimals used within the therapeutic range. Neonatal Intensive Care Unit(NICU) needsa system for the calculation and preparation of drugs [2].

One example is a calculation of the total amount needed in the NICU for ampicillin use for one week
Dose*weight in Kg*frequency*number of babies *7 days divided by the concentration of ampoule to find out the total number needed.
The second example is drugs used for infusion like Vancomycin
Dose*weight in Kg *frequency*number of babies*7 days divided by concentration of vial to find out the total number needed.

Doses calculated from leaflets like normal immunoglobulin that is not mentioned by PNF, replacement therapy in primary immunodeficiency disorders/replacement therapy in secondary immunodeficiency disordersby I.V. infusion in neonate [3]. Consult product literature, usingthis type of immunoglobulin necessitates certain procedures and several precautions regarding administration. So, the total dose is one gm/kg equal to 10ml/kg from a product concentration of 100mg per ml.To be administered in two steps:initial rate is 0.5ml per kg over 30 min if no problems then a gradual increase upto 6ml per kg per hour. The challenges will be the ability of pharmacists in this hard environment to calculate communicate, and to avoid drug interactions.

Conclusion: The pharmacist involved in the delivery of pharmacy services to a pediatric or neonatal patient population must be well trained as a generalized, that is, to understand all of the,modern basic pharmacy programs, such as unit dose and I. V. additives. Pharmacists must also have all the basic skills of general pharmacy practice, such as understanding compounding, drug incompatibilities, drug excretion, and dosing formulation.


1. Ku LC, Smith PB (2015) Dosing in neonates: Special considerations in physiology and trial design. Pediatric Research. 77: 2-9. doi: 10.1038/pr.2014.143
2. DribikaE, Hashad N, Ramadan R, Ertemi FS (2022) A protocol of drug and infusion fluid: Preparation, administration, compatibility and stability in neonatal in intensive care unit. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2 (2): 3 - 6. doi.org/10.5281/zenodo.6780436
3. British National Formulary (2007) BNF 54. Royal Pharmaceutical Society of Great Britain. BMJ London, UK. ISBN: 9780853697367

Citation :

Neonat Hashad NS (2023) Neonate dosing in the intensive care unit. Mediterr J Pharm Pharm Sci. 3 (3): 60-61. https://doi.org/10.5281/zenodo.8393129

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